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Friday, January 6, 2012

Fwd: PLoS Genetics Volume 7(12) December 2011



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From: PLoS Genetics <news@lists.plos.org>
Date: Tue, Jan 3, 2012 at 5:50 PM
Subject: PLoS Genetics Volume 7(12) December 2011
To: technologiclee@gmail.com


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PLoS Genetics
Volume 7(12) December 2011

View Table of Contents on web site



Interview

The Connection between Space and Thinking: An Interview with Rafael Viñoly
Jane Gitschier

Perspective

An Anti-Checkpoint Activity for Rif1
Yaniv Harari, Linda Rubinstein, Martin Kupiec

Research Articles

The Caenorhabditis elegans Synthetic Multivulva Genes Prevent Ras Pathway Activation by Tightly Repressing Global Ectopic Expression of lin-3 EGF
Adam M. Saffer, Dong Hyun Kim, Alexander van Oudenaarden, H. Robert Horvitz

Transcription Is Required to Establish Maternal Imprinting at the Prader-Willi Syndrome and Angelman Syndrome Locus
Emily Y. Smith, Christopher R. Futtner, Stormy J. Chamberlain, Karen A. Johnstone, James L. Resnick

Substitutions in the Amino-Terminal Tail of Neurospora Histone H3 Have Varied Effects on DNA Methylation
Keyur K. Adhvaryu, Emanuela Berge, Hisashi Tamaru, Michael Freitag, Eric U. Selker

Duox, Flotillin-2, and Src42A Are Required to Activate or Delimit the Spread of the Transcriptional Response to Epidermal Wounds in Drosophila
Michelle T. Juarez, Rachel A. Patterson, Efren Sandoval-Guillen, William McGinnis

Autosomal Recessive Dilated Cardiomyopathy due to DOLK Mutations Results from Abnormal Dystroglycan O-Mannosylation
Dirk J. Lefeber, Arjan P. M. de Brouwer, Eva Morava, Moniek Riemersma, Janneke H. M. Schuurs-Hoeijmakers, Birgit Absmanner, Kiek Verrijp, Willem M. R. van den Akker, Karin Huijben, Gerry Steenbergen, Jeroen van Reeuwijk, Adam Jozwiak, Nili Zucker, Avraham Lorber, Martin Lammens, Carlos Knopf, Hans van Bokhoven, Stephanie Grünewald, Ludwig Lehle, Livia Kapusta, Hanna Mandel, Ron A. Wevers

MAPK/ERK Signaling Regulates Insulin Sensitivity to Control Glucose Metabolism in Drosophila
Wei Zhang, Barry J. Thompson, Ville Hietakangas, Stephen M. Cohen

The RNA Silencing Enzyme RNA Polymerase V Is Required for Plant Immunity
Ana López, Vicente Ramírez, Javier García-Andrade, Victor Flors, Pablo Vera

Interspecific Sex in Grass Smuts and the Genetic Diversity of Their Pheromone-Receptor System
Ronny Kellner, Evelyn Vollmeister, Michael Feldbrügge, Dominik Begerow

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network
M. Catarina Silva, Susan Fox, Monica Beam, Happy Thakkar, Margarida D. Amaral, Richard I. Morimoto

Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals
Yingleong Chan, Oddgeir L. Holmen, Andrew Dauber, Lars Vatten, Aki S. Havulinna, Frank Skorpen, Kirsti Kvaløy, Kaisa Silander, Thutrang T. Nguyen, Cristen Willer, Michael Boehnke, Markus Perola, Aarno Palotie, Veikko Salomaa, Kristian Hveem, Timothy M. Frayling, Joel N. Hirschhorn, Michael N. Weedon

DNA Methylation of the Gonadal Aromatase (cyp19a) Promoter Is Involved in Temperature-Dependent Sex Ratio Shifts in the European Sea Bass
Laia Navarro-Martín, Jordi Viñas, Laia Ribas, Noelia Díaz, Arantxa Gutiérrez, Luciano Di Croce, Francesc Piferrer

Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1
You-Ying Chau, David Brownstein, Heidi Mjoseng, Wen-Chin Lee, Natalija Buza-Vidas, Claus Nerlov, Sten Eirik Jacobsen, Paul Perry, Rachel Berry, Anna Thornburn, David Sexton, Nik Morton, Peter Hohenstein, Elisabeth Freyer, Kay Samuel, Rob van't Hof, Nicholas Hastie

A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken
Ben Dorshorst, Anna-Maja Molin, Carl-Johan Rubin, Anna M. Johansson, Lina Strömstedt, Manh-Hung Pham, Chih-Feng Chen, Finn Hallböök, Chris Ashwell, Leif Andersson

Candidate Gene Screen in the Red Flour Beetle Tribolium Reveals Six3 as Ancient Regulator of Anterior Median Head and Central Complex Development
Nico Posnien, Nikolaus Dieter Bernhard Koniszewski, Hendrikje Jeannette Hein, Gregor Bucher

Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation
Xiaoxi Wang, Lei Pan, Su Wang, Jian Zhou, William McDowell, Jungeun Park, Jeff Haug, Karen Staehling, Hong Tang, Ting Xie

Ror2 Enhances Polarity and Directional Migration of Primordial Germ Cells
Diana J. Laird, Svetlana Altshuler-Keylin, Michael D. Kissner, Xin Zhou, Kathryn V. Anderson

Azospirillum Genomes Reveal Transition of Bacteria from Aquatic to Terrestrial Environments
Florence Wisniewski-Dyé, Kirill Borziak, Gurusahai Khalsa-Moyers, Gladys Alexandre, Leonid O. Sukharnikov, Kristin Wuichet, Gregory B. Hurst, W. Hayes McDonald, Jon S. Robertson, Valérie Barbe, Alexandra Calteau, Zoé Rouy, Sophie Mangenot, Claire Prigent-Combaret, Philippe Normand, Mickaël Boyer, Patricia Siguier, Yves Dessaux, Claudine Elmerich, Guy Condemine, Ganisan Krishnen, Ivan Kennedy, Andrew H. Paterson, Victor González, Patrick Mavingui, Igor B. Zhulin

A High-Resolution Whole-Genome Map of Key Chromatin Modifications in the Adult Drosophila melanogaster
Hang Yin, Sarah Sweeney, Debasish Raha, Michael Snyder, Haifan Lin

Identification of Evolutionarily Conserved Exons as Regulated Targets for the Splicing Activator Tra2β in Development
Sushma Grellscheid, Caroline Dalgliesh, Markus Storbeck, Andrew Best, Yilei Liu, Miriam Jakubik, Ylva Mende, Ingrid Ehrmann, Tomaz Curk, Kristina Rossbach, Cyril F. Bourgeois, James Stévenin, David Grellscheid, Michael S. Jackson, Brunhilde Wirth, David J. Elliott

HIF-1 Regulates Iron Homeostasis in Caenorhabditis elegans by Activation and Inhibition of Genes Involved in Iron Uptake and Storage
Steven Joshua Romney, Ben S. Newman, Colin Thacker, Elizabeth A. Leibold

Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone
Jane I. Lin, Naomi C. Mitchell, Marina Kalcina, Elly Tchoubrieva, Mary J. Stewart, Steven J. Marygold, Cherryl D. Walker, George Thomas, Sally J. Leevers, Richard B. Pearson, Leonie M. Quinn, Ross D. Hannan

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains
Nicolas Siaud, Maria A. Barbera, Akinori Egashira, Isabel Lam, Nicole Christ, Katharina Schlacher, Bing Xia, Maria Jasin

Ancestral Components of Admixed Genomes in a Mexican Cohort
Nicholas A. Johnson, Marc A. Coram, Mark D. Shriver, Isabelle Romieu, Gregory S. Barsh, Stephanie J. London, Hua Tang

A Functional Phylogenomic View of the Seed Plants
Ernest K. Lee, Angelica Cibrian-Jaramillo, Sergios-Orestis Kolokotronis, Manpreet S. Katari, Alexandros Stamatakis, Michael Ott, Joanna C. Chiu, Damon P. Little, Dennis Wm. Stevenson, W. Richard McCombie, Robert A. Martienssen, Gloria Coruzzi, Rob DeSalle

Target Site Recognition by a Diversity-Generating Retroelement
Huatao Guo, Longping V. Tse, Angela W. Nieh, Elizabeth Czornyj, Steven Williams, Sabrina Oukil, Vincent B. Liu, Jeff F. Miller

A Densely Interconnected Genome-Wide Network of MicroRNAs and Oncogenic Pathways Revealed Using Gene Expression Signatures
Chia Huey Ooi, Hue Kian Oh, Hannah Zhu'Ai Wang, Angie Lay Keng Tan, Jeanie Wu, Minghui Lee, Sun Young Rha, Hyun Cheol Chung, David Marc Virshup, Patrick Tan

A Novel Checkpoint and RPA Inhibitory Pathway Regulated by Rif1
Yuan Xue, Michael D. Rushton, Laura Maringele

Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types
Michael J. Ziller, Fabian Müller, Jing Liao, Yingying Zhang, Hongcang Gu, Christoph Bock, Patrick Boyle, Charles B. Epstein, Bradley E. Bernstein, Thomas Lengauer, Andreas Gnirke, Alexander Meissner

Mining the LIPG Allelic Spectrum Reveals the Contribution of Rare and Common Regulatory Variants to HDL Cholesterol
Sumeet A. Khetarpal, Andrew C. Edmondson, Avanthi Raghavan, Hemanth Neeli, Weijun Jin, Karen O. Badellino, Serkalem Demissie, Alisa K. Manning, Stephanie L. DerOhannessian, Megan L. Wolfe, L. Adrienne Cupples, Mingyao Li, Sekar Kathiresan, Daniel J. Rader

The FGFR4-G388R Polymorphism Promotes Mitochondrial STAT3 Serine Phosphorylation to Facilitate Pituitary Growth Hormone Cell Tumorigenesis
Toru Tateno, Sylvia L. Asa, Lei Zheng, Thomas Mayr, Axel Ullrich, Shereen Ezzat

Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes
Laure Escoubet-Lozach, Christopher Benner, Minna U. Kaikkonen, Jean Lozach, Sven Heinz, Nathan J. Spann, Andrea Crotti, Josh Stender, Serena Ghisletti, Donna Reichart, Christine S. Cheng, Rosa Luna, Colleen Ludka, Roman Sasik, Ivan Garcia-Bassets, Alexander Hoffmann, Shankar Subramaniam, Gary Hardiman, Michael G. Rosenfeld, Christopher K. Glass

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology
Dick Jaarsma, Ingrid van der Pluijm, Monique C. de Waard, Elize D. Haasdijk, Renata Brandt, Marcel Vermeij, Yvonne Rijksen, Alex Maas, Harry van Steeg, Jan H. J. Hoeijmakers, Gijsbertus T. J. van der Horst

A Comprehensive Analysis of Shared Loci between Systemic Lupus Erythematosus (SLE) and Sixteen Autoimmune Diseases Reveals Limited Genetic Overlap
Paula S. Ramos, Lindsey A. Criswell, Kathy L. Moser, Mary E. Comeau, Adrienne H. Williams, Nicholas M. Pajewski, Sharon A. Chung, Robert R. Graham, Raphael Zidovetzki, Jennifer A. Kelly, Kenneth M. Kaufman, Chaim O. Jacob, Timothy J. Vyse, Betty P. Tsao, Robert P. Kimberly, Patrick M. Gaffney, Marta E. Alarcón-Riquelme, John B. Harley, Carl D. Langefeld, for The International Consortium on the Genetics of Systemic Erythematosus (SLEGEN)

An Assessment of the Individual and Collective Effects of Variants on Height Using Twins and a Developmentally Informative Study Design
Scott I. Vrieze, Matt McGue, Michael B. Miller, Lisa N. Legrand, Nicholas J. Schork, William G. Iacono

Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans
Maxime Rotival, Tanja Zeller, Philipp S. Wild, Seraya Maouche, Silke Szymczak, Arne Schillert, Raphaele Castagné, Arne Deiseroth, Carole Proust, Jessy Brocheton, Tiphaine Godefroy, Claire Perret, Marine Germain, Medea Eleftheriadis, Christoph R. Sinning, Renate B. Schnabel, Edith Lubos, Karl J. Lackner, Heidi Rossmann, Thomas Münzel, Augusto Rendon, Cardiogenics Consortium, Jeanette Erdmann, Panos Deloukas, Christian Hengstenberg, Patrick Diemert, Gilles Montalescot, Willem H. Ouwehand, Nilesh J. Samani, Heribert Schunkert, David-Alexandre Tregouet, Andreas Ziegler, Alison H. Goodall, François Cambien, Laurence Tiret, Stefan Blankenberg

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus
Michael Blatzer, Bridget M. Barker, Sven D. Willger, Nicola Beckmann, Sara J. Blosser, Elizabeth J. Cornish, Aurelien Mazurie, Nora Grahl, Hubertus Haas, Robert A. Cramer

Hierarchical Generalized Linear Models for Multiple Groups of Rare and Common Variants: Jointly Estimating Group and Individual-Variant Effects
Nengjun Yi, Nianjun Liu, Degui Zhi, Jun Li

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome
A. P. Jason de Koning, Wanjun Gu, Todd A. Castoe, Mark A. Batzer, David D. Pollock

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
María S. Domínguez-Sánchez, Sonia Barroso, Belén Gómez-González, Rosa Luna, Andrés Aguilera

The Fission Yeast Stress-Responsive MAPK Pathway Promotes Meiosis via the Phosphorylation of Pol II CTD in Response to Environmental and Feedback Cues
Yuko Sukegawa, Akira Yamashita, Masayuki Yamamoto

Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes
Kyudong Han, Dianne I. Lou, Sara L. Sawyer

A Population Genetics-Phylogenetics Approach to Inferring Natural Selection in Coding Sequences
Daniel J. Wilson, Ryan D. Hernandez, Peter Andolfatto, Molly Przeworski

Targeted Proteolysis of Plectin Isoform 1a Accounts for Hemidesmosome Dysfunction in Mice Mimicking the Dominant Skin Blistering Disease EBS-Ogna
Gernot Walko, Nevena Vukasinovic, Karin Gross, Irmgard Fischer, Sabrina Sibitz, Peter Fuchs, Siegfried Reipert, Ute Jungwirth, Walter Berger, Ulrich Salzer, Oliviero Carugo, Maria J. Castañón, Gerhard Wiche

Widespread Cotranslational Formation of Protein Complexes
Caia D. S. Duncan, Juan Mata

Charcot-Marie-Tooth–Linked Mutant GARS Is Toxic to Peripheral Neurons Independent of Wild-Type GARS Levels
William W. Motley, Kevin L. Seburn, Mir Hussain Nawaz, Kathy E. Miers, Jun Cheng, Anthony Antonellis, Eric D. Green, Kevin Talbot, Xiang-Lei Yang, Kenneth H. Fischbeck, Robert W. Burgess

Genome-Wide Meta-Analysis of Five Asian Cohorts Identifies PDGFRA as a Susceptibility Locus for Corneal Astigmatism
Qiao Fan, Xin Zhou, Chiea-Chuen Khor, Ching-Yu Cheng, Liang-Kee Goh, Xueling Sim, Wan-Ting Tay, Yi-Ju Li, Rick Twee-Hee Ong, Chen Suo, Belinda Cornes, Mohammad Kamran Ikram, Kee-Seng Chia, Mark Seielstad, Jianjun Liu, Eranga Vithana, Terri L. Young, E.-Shyong Tai, Tien-Yin Wong, Tin Aung, Yik-Ying Teo, Seang-Mei Saw

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate
Sandra Blanco, Agata Kurowski, Jennifer Nichols, Fiona M. Watt, Salvador Aznar Benitah, Michaela Frye

The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved
Izumi Miyabe, Thomas A. Kunkel, Antony M. Carr


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