Monday, May 2, 2011
Scaffolded DNA origami enables the programmable synthesis of complex DNA-based nanostructures with a broad range of potential scientific and industrial applications [1-6]. DNA origami entails folding a multiple kilobase single-stranded ‘scaffold’ DNA molecule into a custom shape using a set of shorter, single-stranded ‘staple’ oligonucleotides. The effective design of complex DNA origami shapes promises to benefit greatly from computational prediction of the expected solution shape and mechanical properties of conceptual designs prior to initiating cost-intensive staple oligonucleotide synthesis. Computational feedback is particularly useful in the design of sophisticated multi-layer structures that include curved or twisted elements . With this online resource we offer to designers of DNA origami the computational prediction of single- and multi-layer DNA origami structures, including their mean deformed 3D conformation and conformational flexibility. Analysis is performed using a finite-element-based modeling framework for DNA with single base-pair resolution, with input provided by design files created using caDNAno  on a honeycomb  or square lattice . The utility of the framework is illustrated on the Examples & Applications page of this website, where several sophisticated linear and non-linear structures including curvature and twist are predicted. Practical information on how to approach the design and production of DNA origami shapes can be found at DNA-origami.org and in the following primer on scaffolded DNA origami .
From: Sam Kronick <email@example.com>
Date: Mon, May 2, 2011 at 2:55 PM
Subject: [Open Manufacturing] Spaceframe Bikes
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The NovoTTF (TTF stands for tumor treating fields) is unlike any other treatment currently available for brain tumors. It’s essentially a battery pack that a patient can carry around. The device weighs about 6 pounds and it powers several electrodes that are attached to the patient’s shaved scalp, directly over the area of the tumor. When turned on, the NovoTTF generates a continuous low intensity, intermediate frequency electric field that affects dividing cells. Uncontrollable cell division is one of the characteristics of malignant cancers and most chemotherapeutic agents are also designed to target these cells as opposed to relatively slow growing healthy cells. An article published in the journal PNAS in 2007 details how the NovoTTF works against dividing cells. Suffice it to say that the alternating current generated by the NovoTTF disrupts the normal function of a cell’s electrically charged molecules that are important for cell division. As most normal brain cells don’t undergo constant cell division, the NovoTTF is able to leave them unharmed.
What is this project about?
Help OpenCores create a "super-low-cost" SoC ASIC component based on the OpenRISC processor. This ASIC will then be offered for sale to the community to use freely in any products, especially for the donors. Your donation is very important allowing us to implement the design into a cost-efficient ASIC technology.
Please help us "revolutionize" the electronic hardware industry and to make the semiconductor giants tremble, by making a donation to design/manufacture an ASIC-component based on the world's only "true" open-source 32-bit RISC processor supporting Linux (the OpenRISC processor from OpenCores.org). We want to provide an alternative to the profit-hunting semiconductor giants who only provide "cost efficient prices" to large multi-national companies. We want to make it feasible to compete on even and fair conditions, which would be possible if we ALL contribute to create a universal OpenRISC processor ASIC component. This hardware development approached has never been done before in history, and we hope that this first project will start a trend so that we, together, can develop more "true" open-source community-funded SoC ASICs in the future.
The plan is to develop a complete SoC design (System-on-Chip) and implement it into an ASIC-component, and then offer it back to the OpenCores community as a "super-low-cost" processor based SoC ASIC-component, that can be used to develop commercial products without any restrictions or royalties. A development board will also be developed using this OpenRISC-ASIC running Linux, enabling users to develop complete cost-efficient Linux based products.
More detailed technical information about the SoC-design is available at the link below:
OpenRISC ASIC draft specification
Together we can change the electronics industry, by donating this project.
We really encourage ALL members in our community to "pitch in" and help us make this project real. Please also help us spread this message through out the world to other communities, in other words "the more the merrier".
We hope that our efforts and massive contribution to OpenCores and with the OpenRISC processor development proves the fact that we FULLY embrace and support the "true" open-source methodology.
All donations count, whether it's $1 or $10,000. The most important thing is that we can collect enough money so that we can afford producing an ASIC, which is quite expensive, but on the other hand will provide the lowest possible unit-cost which is super critical in order to enable our community to create low-cost commercial products.
We will have a "donation list" showing all the donors, with a top-50 and one list with all donors visible without showing the donated amount. We will of course also accept anonymous donations, for those who might work for a large Semiconductor company :-)
Please see the FAQ for more questions.